Homo sapiens Gene: MAD1L1
Summary
InnateDB Gene IDBG-6719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAD1L1
Gene Name MAD1 mitotic arrest deficient-like 1 (yeast)
Synonyms MAD1; PIG9; TP53I9; TXBP181;
Species Homo sapiens
Ensembl Gene ENSG00000002822
Encoded Proteins
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1 mitotic arrest deficient-like 1 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:1815793-2233243
Strand Reverse strand
Band p22.3
Transcripts
ENST00000265854 ENSP00000265854
ENST00000399654 ENSP00000382562
ENST00000406869 ENSP00000385334
ENST00000402746 ENSP00000384155
ENST00000450235 ENSP00000394886
ENST00000437877 ENSP00000394069
ENST00000438959 ENSP00000414877
ENST00000444373 ENSP00000393037
ENST00000421113 ENSP00000397417
ENST00000445959 ENSP00000401901
ENST00000429625 ENSP00000413139
ENST00000455998 ENSP00000390099
ENST00000429779 ENSP00000395457
ENST00000481633
ENST00000496548
ENST00000468372
ENST00000477172
ENST00000464742
ENST00000491858
ENST00000483165
ENST00000459731
ENST00000486340
ENST00000469871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000089 mitotic metaphase
GO:0000090 mitotic anaphase
GO:0000093 mitotic telophase
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
GO:0007094 mitotic spindle assembly checkpoint
GO:0090235 regulation of metaphase plate congression
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Mitotic Spindle Checkpoint pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway
Amplification of signal from the kinetochores pathway
Resolution of Sister Chromatid Cohesion pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
C-MYB transcription factor network
Cross-References
SwissProt Q9Y6D9
TrEMBL C9J9H5 C9JJ38 C9JKI7 C9JTA2 C9JX80 C9K086
UniProt Splice Variant
Entrez Gene 8379
UniGene
RefSeq NM_001013836 NM_001013837 NM_003550 XM_005249878 XM_006715788 XM_005249876
HUGO HGNC:6762
OMIM 602686
CCDS CCDS43539
HPRD 04065
IMGT
EMBL AC005282 AC006433 AC069288 AC104129 AC110781 AF083811 AF123318 BC009964 U33822
GenPept AAC52059 AAD20359 AAD24498 AAH09964 AAP21876 AAS07503
RNA Seq Atlas 8379