InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN5

Summary

InnateDB Protein

IDBP-292500.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN5

Protein Name

claudin 5

Synonyms

AWAL; BEC1; CPETRL1; TMVCF;

Species

Homo sapiens

Ensembl Protein

ENSP00000385477

InnateDB Gene

IDBG-1386 (CLDN5)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016338	calcium-independent cell-cell adhesion
GO:0042552	myelination

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0033270	paranode region of axon
GO:0043220	Schmidt-Lanterman incisure
GO:0070062	extracellular vesicular exosome