Version 5.4
Homo sapiens Protein: COMT
Summary
InnateDB Protein IDBP-292533.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMT
Protein Name catechol-O-methyltransferase
Synonyms HEL-S-98n;
Species Homo sapiens
Ensembl Protein ENSP00000383966
InnateDB Gene IDBG-1506 (COMT)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0032259 methylation
GO:0042135 neurotransmitter catabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002935 O-methyltransferase, family 3
IPR017128 Catechol O-methyltransferase, eukaryotic
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01596
PRINTS
PIRSF PIRSF037177
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q7KZP0
UniProt Splice Variant
Entrez Gene 1312
UniGene Hs.370408
RefSeq
HUGO HGNC:2228
OMIM 116790
CCDS
HPRD 00284
IMGT
EMBL AC000080 AC000090 AC005663 BT007125 HQ262572 HQ262573
GenPept AAP35789 AEA30239 AEA30240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca