InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH3BP4

Summary

InnateDB Protein

IDBP-292881.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3BP4

Protein Name

SH3-domain binding protein 4

Synonyms

BOG25; TTP;

Species

Homo sapiens

Ensembl Protein

ENSP00000386862

InnateDB Gene

IDBG-83995 (SH3BP4)

Protein Structure

UniProt Annotation

Function

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269PubMed:16325581, ECO:0000269PubMed:22575674}.

Subcellular Localization

Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269PubMed:10644451, ECO:0000269PubMed:15616480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005515	protein binding
GO:0017016	Ras GTPase binding
GO:0042802	identical protein binding

Biological Process

GO:0006897	endocytosis
GO:0008285	negative regulation of cell proliferation
GO:0010508	positive regulation of autophagy
GO:0030308	negative regulation of cell growth
GO:0032007	negative regulation of TOR signaling
GO:0034260	negative regulation of GTPase activity
GO:0050790	regulation of catalytic activity
GO:0061462	protein localization to lysosome
GO:0071230	cellular response to amino acid stimulus