Version 5.4
Homo sapiens Gene: SH3BP4
Summary
InnateDB Gene IDBG-83995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP4
Gene Name SH3-domain binding protein 4
Synonyms BOG25; TTP
Species Homo sapiens
Ensembl Gene ENSG00000130147
Encoded Proteins
IDBP-83997
SH3-domain binding protein 4
IDBP-246530
SH3-domain binding protein 4
IDBP-292881
SH3-domain binding protein 4
IDBP-389426
SH3-domain binding protein 4
IDBP-389427
SH3-domain binding protein 4
IDBP-389428
SH3-domain binding protein 4
IDBP-389429
SH3-domain binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:234951973-235055714
Strand Forward strand
Band q37.2
Transcripts
ENST00000344528 ENSP00000340237
ENST00000392011 ENSP00000375867
ENST00000409212 ENSP00000386862
ENST00000416021 ENSP00000403251
ENST00000444916 ENSP00000387995
ENST00000446904 ENSP00000415391
ENST00000454947 ENSP00000414740
ENST00000484097
ENST00000489601
ENST00000462602
ENST00000493436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0008285 negative regulation of cell proliferation
GO:0010508 positive regulation of autophagy
GO:0030308 negative regulation of cell growth
GO:0032007 negative regulation of TOR signaling
GO:0034260 negative regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0061462 protein localization to lysosome
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005905 coated pit
GO:0030136 clathrin-coated vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036206
View Gene Order
ENSBTAG00000013869
Not yet available
Cross-References
SwissProt Q9P0V3
TrEMBL B4E2S1 C9JED2 C9JF25 C9JRG1 C9JWW6
UniProt Splice Variant
Entrez Gene 23677
UniGene Hs.516777 Hs.639304
RefSeq NM_014521
HUGO HGNC:10826
OMIM 605611
CCDS CCDS2513
HPRD 09285
IMGT
EMBL AC010148 AC114814 AF015043 AF147747 AK304398 BC057396 DQ232895
GenPept AAD01551 AAF33022 AAH57396 AAY14916 AAY24025 ABB18377 BAG65233
RNA Seq Atlas 23677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca