InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1H3

Summary

InnateDB Protein

IDBP-293077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H3

Protein Name

nuclear receptor subfamily 1, group H, member 3

Synonyms

LXR-a; LXRA; RLD-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000384745

InnateDB Gene

IDBG-42877 (NR1H3)

Protein Structure

UniProt Annotation

Function

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	45 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0015485	cholesterol binding
GO:0032810	sterol response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010870	positive regulation of receptor biosynthetic process
GO:0010875	positive regulation of cholesterol efflux
GO:0010887	negative regulation of cholesterol storage
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032369	negative regulation of lipid transport
GO:0032376	positive regulation of cholesterol transport
GO:0032570	response to progesterone
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0042632	cholesterol homeostasis
GO:0042752	regulation of circadian rhythm
GO:0043031	negative regulation of macrophage activation
GO:0043277	apoptotic cell clearance
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048550	negative regulation of pinocytosis
GO:0050728	negative regulation of inflammatory response
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055088	lipid homeostasis
GO:0055092	sterol homeostasis
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0070328	triglyceride homeostasis
GO:0071222	cellular response to lipopolysaccharide
GO:0090188	negative regulation of pancreatic juice secretion
GO:0090341	negative regulation of secretion of lysosomal enzymes
GO:2000188	regulation of cholesterol homeostasis
GO:2000189	positive regulation of cholesterol homeostasis

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR023257 Liver X receptor

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR02034

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt