Version 5.4
Homo sapiens Gene: NR1H3
Summary
InnateDB Gene IDBG-42877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR1H3
Gene Name nuclear receptor subfamily 1, group H, member 3
Synonyms LXR-a; LXRA; RLD-1
Species Homo sapiens
Ensembl Gene ENSG00000025434
Encoded Proteins
IDBP-239613
nuclear receptor subfamily 1, group H, member 3
IDBP-293080
nuclear receptor subfamily 1, group H, member 3
IDBP-293077
nuclear receptor subfamily 1, group H, member 3
IDBP-293076
nuclear receptor subfamily 1, group H, member 3
IDBP-373071
nuclear receptor subfamily 1, group H, member 3
IDBP-373080
nuclear receptor subfamily 1, group H, member 3
IDBP-373086
nuclear receptor subfamily 1, group H, member 3
IDBP-373087
nuclear receptor subfamily 1, group H, member 3
IDBP-373089
nuclear receptor subfamily 1, group H, member 3
IDBP-373092
nuclear receptor subfamily 1, group H, member 3
IDBP-373093
nuclear receptor subfamily 1, group H, member 3
IDBP-373095
nuclear receptor subfamily 1, group H, member 3
IDBP-373099
nuclear receptor subfamily 1, group H, member 3
IDBP-373103
nuclear receptor subfamily 1, group H, member 3
IDBP-481974
nuclear receptor subfamily 1, group H, member 3
IDBP-596950
nuclear receptor subfamily 1, group H, member 3
IDBP-583631
nuclear receptor subfamily 1, group H, member 3
IDBP-590498
nuclear receptor subfamily 1, group H, member 3
IDBP-811966
nuclear receptor subfamily 1, group H, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21492741
NR1H3 repressed IRF3- or IRF7-induced transactivation of the interferon-beta promoter and NDV infection further potentiated the repressive effect in dendritic cells. (Demonstrated in murine model)
Entrez Gene
Summary The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47248300-47269032
Strand Forward strand
Band p11.2
Transcripts
ENST00000395397 ENSP00000378793
ENST00000407404 ENSP00000385801
ENST00000405853 ENSP00000384745
ENST00000405576 ENSP00000385073
ENST00000436778 ENSP00000403798
ENST00000444396 ENSP00000391005
ENST00000457932 ENSP00000413095
ENST00000412937 ENSP00000412636
ENST00000449369 ENSP00000415591
ENST00000419652 ENSP00000407716
ENST00000441012 ENSP00000387946
ENST00000437276 ENSP00000396132
ENST00000436029 ENSP00000403696
ENST00000420369 ENSP00000406692
ENST00000495866
ENST00000481020
ENST00000487913
ENST00000476086
ENST00000486991
ENST00000461778
ENST00000467728 ENSP00000420656
ENST00000498548
ENST00000473222
ENST00000483882
ENST00000481889 ENSP00000433271
ENST00000462051
ENST00000494018
ENST00000527464
ENST00000529540
ENST00000531660 ENSP00000434650
ENST00000532630
ENST00000525441
ENST00000530310
ENST00000527949 ENSP00000432073
ENST00000616973 ENSP00000477707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 45 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015485 cholesterol binding
GO:0032810 sterol response element binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010870 positive regulation of receptor biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0030522 intracellular receptor signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0032570 response to progesterone
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0042632 cholesterol homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043031 negative regulation of macrophage activation
GO:0043277 apoptotic cell clearance
GO:0043401 steroid hormone mediated signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048550 negative regulation of pinocytosis
GO:0050728 negative regulation of inflammatory response
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070328 triglyceride homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:0090188 negative regulation of pancreatic juice secretion
GO:0090341 negative regulation of secretion of lysosomal enzymes
GO:2000188 regulation of cholesterol homeostasis
GO:2000189 positive regulation of cholesterol homeostasis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa03320
PPAR signaling pathway pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438863
RefSeq NM_001130101 NM_001130102 NM_001251934 NM_001251935 NM_005693 XM_005252705 XM_005252709 XM_005252710 XM_005252713 XM_006718112 XM_006718113 XM_006718114 XM_006718115 XM_006718116
HUGO
OMIM
CCDS CCDS44584 CCDS44585 CCDS73285 CCDS7929
HPRD 07211
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca