InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XPO1

Summary

InnateDB Protein

IDBP-293100.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPO1

Protein Name

exportin 1 (CRM1 homolog, yeast)

Synonyms

CRM1; emb; exp1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385559

InnateDB Gene

IDBG-53335 (XPO1)

Protein Structure

UniProt Annotation

Function

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269PubMed:14612415, ECO:0000269PubMed:15574332, ECO:0000269PubMed:20921223, ECO:0000269PubMed:9311922, ECO:0000269PubMed:9323133, ECO:0000269PubMed:9837918}.

Subcellular Localization

Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269PubMed:9049309, ECO:0000269PubMed:9368044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 204 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	204 [view]
Protein-Protein	202 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005215	transporter activity
GO:0005487	nucleocytoplasmic transporter activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0000056	ribosomal small subunit export from nucleus
GO:0000278	mitotic cell cycle
GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051028	mRNA transport
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005642	annulate lamellae
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015030	Cajal body
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle