InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XPO1

Summary

InnateDB Gene

IDBG-53335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPO1

Gene Name

exportin 1 (CRM1 homolog, yeast)

Synonyms

CRM1; emb; exp1

Species

Homo sapiens

Ensembl Gene

ENSG00000082898

Encoded Proteins

IDBP-293098

exportin 1 (CRM1 homolog, yeast)

IDBP-293093

exportin 1 (CRM1 homolog, yeast)

IDBP-293100

exportin 1 (CRM1 homolog, yeast)

IDBP-377361

exportin 1 (CRM1 homolog, yeast)

IDBP-377375

exportin 1 (CRM1 homolog, yeast)

IDBP-377378

exportin 1 (CRM1 homolog, yeast)

IDBP-377379

exportin 1 (CRM1 homolog, yeast)

IDBP-377385

exportin 1 (CRM1 homolog, yeast)

IDBP-377387

exportin 1 (CRM1 homolog, yeast)

IDBP-377391

exportin 1 (CRM1 homolog, yeast)

IDBP-377396

exportin 1 (CRM1 homolog, yeast)

IDBP-377398

exportin 1 (CRM1 homolog, yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:61477849-61538626

Strand

Reverse strand

Band

p15

Transcripts

ENST00000401558	ENSP00000384863
ENST00000404992	ENSP00000385942
ENST00000406957	ENSP00000385559
ENST00000428210	ENSP00000407170
ENST00000437159	ENSP00000388927
ENST00000451765	ENSP00000413853
ENST00000443240	ENSP00000406428
ENST00000420673	ENSP00000393484
ENST00000422552	ENSP00000408190
ENST00000457483	ENSP00000394951
ENST00000449444	ENSP00000406819
ENST00000436018	ENSP00000390843
ENST00000481073
ENST00000461407
ENST00000492182
ENST00000494468
ENST00000469337
ENST00000460037
ENST00000475744
ENST00000489954
ENST00000476585
ENST00000468259
ENST00000481214
ENST00000495003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 204 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	204 [view]
Protein-Protein	202 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005215	transporter activity
GO:0005487	nucleocytoplasmic transporter activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0019904	protein domain specific binding

Biological Process

GO:0000055	ribosomal large subunit export from nucleus
GO:0000056	ribosomal small subunit export from nucleus
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0010824	regulation of centrosome duplication
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034504	protein localization to nucleus
GO:0042176	regulation of protein catabolic process
GO:0042493	response to drug
GO:0046825	regulation of protein export from nucleus
GO:0051028	mRNA transport
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005642	annulate lamellae
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015030	Cajal body
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020290

View Gene Order

ENSBTAG00000013254

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_150425

Resolution of Sister Chromatid Cohesion pathway

REACT_682

Mitotic Prometaphase pathway

REACT_150471

Separation of Sister Chromatids pathway

REACT_1857

Cyclin A/B1 associated events during G2/M transition pathway

REACT_120727

Downregulation of TGF-beta receptor signaling pathway

REACT_120850

TGF-beta receptor signaling activates SMADs pathway

REACT_25218

HuR stabilizes mRNA pathway

REACT_6190

Rev-mediated nuclear export of HIV RNA pathway

REACT_6179

NEP/NS2 Interacts with the Cellular Export Machinery pathway

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_169107

SMAD4 MH2 Domain Mutants in Cancer pathway

REACT_6167

Influenza Infection pathway

REACT_228096

misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_169219

Loss of Function of SMAD4 in Cancer pathway

REACT_169398

Loss of Function of SMAD2/3 in Cancer pathway

REACT_169122

Signaling by TGF-beta Receptor Complex in Cancer pathway

REACT_11045

Signaling by Wnt pathway

REACT_200731

deactivation of the beta-catenin transactivating complex pathway

REACT_169192

TGFBR2 MSI Frameshift Mutants in Cancer pathway

REACT_111102

Signal Transduction pathway

REACT_169165

SMAD2/3 MH2 Domain Mutants in Cancer pathway

REACT_169435

Loss of Function of TGFBR2 in Cancer pathway

REACT_115566

Cell Cycle pathway

REACT_169103

SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway

REACT_910

M Phase pathway

REACT_6256

HIV Life Cycle pathway

REACT_1275

Mitotic Anaphase pathway

REACT_200777

TCF dependent signaling in response to WNT pathway

REACT_2203

G2/M Transition pathway

REACT_169263

TGFBR1 KD Mutants in Cancer pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_228188

RNF mutants show enhanced WNT signaling and proliferation pathway

REACT_6185

HIV Infection pathway

REACT_169311

Loss of Function of TGFBR1 in Cancer pathway

REACT_169445

TGFBR1 LBD Mutants in Cancer pathway

REACT_6145

Influenza Life Cycle pathway

REACT_21391

Mitotic G2-G2/M phases pathway

REACT_169440

TGFBR2 Kinase Domain Mutants in Cancer pathway

REACT_228279

XAV939 inhibits tankyrase, stabilizing AXIN pathway

REACT_6288

Host Interactions of HIV factors pathway

REACT_6296

Export of Viral Ribonucleoproteins from Nucleus pathway

REACT_6916

Interactions of Rev with host cellular proteins pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_6844

Signaling by TGF-beta Receptor Complex pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

foxopathway

FoxO family signaling

hdac_classi_pathway

Signaling events mediated by HDAC Class I

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

ilk_pathway

Integrin-linked kinase signaling

hdac_classii_pathway

Signaling events mediated by HDAC Class II

nfkappabcanonicalpathway

Canonical NF-kappaB pathway

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

ranbp2pathway

Sumoylation by RanBP2 regulates transcriptional repression

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.370770 Hs.717708

RefSeq

NM_003400 XM_005264546 XM_006712094 XM_006712095 XM_006712096 XM_006712097

HUGO

OMIM

CCDS

CCDS33205

HPRD

03975

IMGT

EMBL

GenPept

RNA Seq Atlas