InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PYCR1

Summary

InnateDB Protein

IDBP-293278.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYCR1

Protein Name

pyrroline-5-carboxylate reductase 1

Synonyms

ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR;

Species

Homo sapiens

Ensembl Protein

ENSP00000384949

InnateDB Gene

IDBG-72880 (PYCR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0006561	proline biosynthetic process
GO:0008652	cellular amino acid biosynthetic process
GO:0034599	cellular response to oxidative stress
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046168	glycerol-3-phosphate catabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000304 Pyrroline-5-carboxylate reductase
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF01210
PF03807

PRINTS

PIRSF

PIRSF000193

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32322