Version 5.4
Homo sapiens Gene: PYCR1
Summary
InnateDB Gene IDBG-72880.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYCR1
Gene Name pyrroline-5-carboxylate reductase 1
Synonyms ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR
Species Homo sapiens
Ensembl Gene ENSG00000183010
Encoded Proteins
IDBP-72882
pyrroline-5-carboxylate reductase 1
IDBP-72884
pyrroline-5-carboxylate reductase 1
IDBP-292393
pyrroline-5-carboxylate reductase 1
IDBP-293278
pyrroline-5-carboxylate reductase 1
IDBP-293277
pyrroline-5-carboxylate reductase 1
IDBP-762439
IDBP-760067
IDBP-762790
IDBP-761431
IDBP-758376
IDBP-758372
IDBP-760035
IDBP-757826
IDBP-764722
IDBP-760868
IDBP-812652
pyrroline-5-carboxylate reductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81932384-81942412
Strand Reverse strand
Band q25.3
Transcripts
ENST00000329875 ENSP00000328858
ENST00000337943 ENSP00000336579
ENST00000403172 ENSP00000385483
ENST00000402252 ENSP00000384949
ENST00000405481 ENSP00000386002
ENST00000581271 ENSP00000464440
ENST00000579366 ENSP00000462398
ENST00000577624 ENSP00000464098
ENST00000585244 ENSP00000462892
ENST00000583564 ENSP00000463225
ENST00000577756 ENSP00000463352
ENST00000585215 ENSP00000463343
ENST00000582198 ENSP00000463226
ENST00000579698 ENSP00000463601
ENST00000584848 ENSP00000463342
ENST00000619204 ENSP00000479793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0005515 protein binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 cellular amino acid biosynthetic process
GO:0034599 cellular response to oxidative stress
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046168 glycerol-3-phosphate catabolic process
GO:0051881 regulation of mitochondrial membrane potential
GO:0055114 oxidation-reduction process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025140
View Gene Order
ENSBTAG00000000042
Not yet available
Pathways
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.163451
RefSeq NM_001282279 NM_001282280 NM_001282281 NM_006907 NM_153824 XM_005256381 XM_006722286
HUGO
OMIM
CCDS CCDS11794 CCDS11795 CCDS62365 CCDS62366
HPRD 01528
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca