Version 5.4
Homo sapiens Protein: PPP1R1C
Summary
InnateDB Protein IDBP-293373.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R1C
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 1C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386359
InnateDB Gene IDBG-76815 (PPP1R1C)
Protein Structure
UniProt Annotation
Function Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis. {ECO:0000269PubMed:18310074, ECO:0000269PubMed:19874272}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, skeletal muscle, liver and testis (at protein level).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0030307 positive regulation of cell growth
GO:0043086 negative regulation of catalytic activity
GO:0051301 cell division
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008466 Protein phosphatase inhibitor, 1DARPP-32
PFAM PF05395
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVI7
PhosphoSite PhosphoSite-Q8WVI7
TrEMBL Q53TF4
UniProt Splice Variant
Entrez Gene 151242
UniGene
RefSeq NP_001248354
HUGO HGNC:14940
OMIM 613240
CCDS CCDS46468
HPRD
IMGT
EMBL AC009962 AC064837 AF494535 BC017943 BX647581
GenPept AAH17943 AAM18054 AAY14914 AAY24129 CAI46089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca