InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHTOP

Summary

InnateDB Protein

IDBP-293426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHTOP

Protein Name

chromatin target of PRMT1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385228

InnateDB Gene

IDBG-102750 (CHTOP)

Protein Structure

UniProt Annotation

Function

Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in an erythroid progenitor cell line derived from peripheral blood. {ECO:0000269PubMed:20688955}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006406	mRNA export from nucleus
GO:0032781	positive regulation of ATPase activity
GO:0051096	positive regulation of helicase activity