Homo sapiens Protein: FBXO11 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-293478.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | FBXO11 | ||||||||||||||||||
Protein Name | F-box protein 11 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000385398 | ||||||||||||||||||
InnateDB Gene | IDBG-51123 (FBXO11) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269PubMed:17098746, ECO:0000269PubMed:22113614, ECO:0000269PubMed:23478441, ECO:0000269PubMed:23478445, ECO:0000269PubMed:23892434}. | ||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. | ||||||||||||||||||
Disease Associations | Note=Defects in FBXO11 may be a cause of diffuse large B- cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas. {ECO:0000269PubMed:22113614}. | ||||||||||||||||||
Tissue Specificity | Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. {ECO:0000269PubMed:11775060}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001810
F-box domain IPR003126 Zinc finger, N-recognin IPR006626 Parallel beta-helix repeat IPR006633 Carbohydrate-binding/sugar hydrolysis domain IPR011050 Pectin lyase fold/virulence factor IPR013993 Zinc finger, N-recognin, metazoa IPR022441 Parallel beta-helix repeat-2 |
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PFAM |
PF00646
PF12937 PF13013 PF02207 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00256
SM00710 SM00722 SM00396 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q86XK2 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q86XK2 | ||||||||||||||||||
TrEMBL | E7EP88 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 80204 | ||||||||||||||||||
UniGene | Hs.732171 | ||||||||||||||||||
RefSeq | NP_079409 | ||||||||||||||||||
HUGO | HGNC:13590 | ||||||||||||||||||
OMIM | 607871 | ||||||||||||||||||
CCDS | CCDS1837 | ||||||||||||||||||
HPRD | 06985 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC006509 AC079807 AF174599 AF176706 AF264714 AF351618 AK022735 AK025477 AK223592 AK292877 AL117620 AY827075 BC012728 BC043258 BC130445 BC136480 CH471053 | ||||||||||||||||||
GenPept | AAF04520 AAF17611 AAF76888 AAH12728 AAH43258 AAI30446 AAI36481 AAN76518 AAV87312 AAY24083 BAB14214 BAB15143 BAD97312 BAF85566 CAB56019 EAX00205 | ||||||||||||||||||