Homo sapiens Gene: FBXO11
Summary
InnateDB Gene IDBG-51123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO11
Gene Name F-box protein 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138081
Encoded Proteins
F-box protein 11
F-box protein 11
F-box protein 11
F-box protein 11
F-box protein 11
F-box protein 11
F-box protein 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:47789316-47905793
Strand Reverse strand
Band p16.3
Transcripts
ENST00000316377 ENSP00000323822
ENST00000405808 ENSP00000385127
ENST00000403359 ENSP00000384823
ENST00000402508 ENSP00000385398
ENST00000434234 ENSP00000402692
ENST00000424163 ENSP00000392272
ENST00000465204
ENST00000470899
ENST00000493962 ENSP00000428118
ENST00000492225
ENST00000480038
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007605 sensory perception of sound
GO:0016567 protein ubiquitination
GO:0035246 peptidyl-arginine N-methylation
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.352677 Hs.605834 Hs.617836 Hs.732171
RefSeq NM_001190274 NM_025133 XM_005264574
HUGO
OMIM
CCDS CCDS1837 CCDS54357
HPRD 06985
IMGT
EMBL
GenPept
RNA Seq Atlas