InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA6

Summary

InnateDB Protein

IDBP-293623.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA6

Protein Name

integrin, alpha 6

Synonyms

CD49f; ITGA6B; VLA-6;

Species

Homo sapiens

Ensembl Protein

ENSP00000386896

InnateDB Gene

IDBG-75102 (ITGA6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043236	laminin binding
GO:0046872	metal ion binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0031589	cell-substrate adhesion
GO:0031668	cellular response to extracellular stimulus
GO:0033627	cell adhesion mediated by integrin
GO:0034329	cell junction assembly
GO:0042327	positive regulation of phosphorylation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046847	filopodium assembly
GO:0050873	brown fat cell differentiation
GO:0050900	leukocyte migration
GO:0071407	cellular response to organic cyclic compound
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0030056	hemidesmosome
GO:0030175	filopodium
GO:0034676	alpha6-beta4 integrin complex
GO:0045178	basal part of cell