Homo sapiens Gene: ITGA6
Summary
InnateDB Gene IDBG-75102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA6
Gene Name integrin, alpha 6
Synonyms CD49f; ITGA6B; VLA-6;
Species Homo sapiens
Ensembl Gene ENSG00000091409
Encoded Proteins
integrin, alpha 6
integrin, alpha 6
integrin, alpha 6
integrin, alpha 6
integrin, alpha 6
integrin, alpha 6
integrin, alpha 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172427354-172506282
Strand Forward strand
Band q31.1
Transcripts
ENST00000264107 ENSP00000264107
ENST00000409080 ENSP00000386896
ENST00000409532 ENSP00000386614
ENST00000412899 ENSP00000413470
ENST00000458358 ENSP00000394169
ENST00000442250 ENSP00000406694
ENST00000416789 ENSP00000388435
ENST00000497107
ENST00000469534
ENST00000470259
ENST00000475302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0031581 hemidesmosome assembly
GO:0031589 cell-substrate adhesion
GO:0031668 cellular response to extracellular stimulus
GO:0033627 cell adhesion mediated by integrin
GO:0034329 cell junction assembly
GO:0042327 positive regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046847 filopodium assembly
GO:0050873 brown fat cell differentiation
GO:0050900 leukocyte migration
GO:0071407 cellular response to organic cyclic compound
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005604 basement membrane
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0030056 hemidesmosome
GO:0030175 filopodium
GO:0034676 alpha6-beta4 integrin complex
GO:0045178 basal part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Cell-Cell communication pathway
Extracellular matrix organization pathway
Cell junction organization pathway
Syndecan interactions pathway
Integrin cell surface interactions pathway
Basigin interactions pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Assembly of collagen fibrils and other multimeric structures pathway
Type I hemidesmosome assembly pathway
Collagen formation pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Integrin family cell surface interactions
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
Alpha6 beta4 integrin-ligand interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133397 Hs.613769
RefSeq NM_000210 NM_001079818
HUGO
OMIM
CCDS CCDS2249 CCDS46451
HPRD 00945
IMGT
EMBL
GenPept
RNA Seq Atlas