Version 5.4
Homo sapiens Protein: SSB
Summary
InnateDB Protein IDBP-293711.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSB
Protein Name Sjogren syndrome antigen B (autoantigen La)
Synonyms La; La/SSB; LARP3;
Species Homo sapiens
Ensembl Protein ENSP00000386636
InnateDB Gene IDBG-74582 (SSB)
Protein Structure
UniProt Annotation
Function Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. {ECO:0000269PubMed:2470590, ECO:0000269PubMed:3192525}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 67 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006396 RNA processing
GO:0006400 tRNA modification
GO:0008334 histone mRNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR002344 Lupus La protein
IPR006630 RNA-binding protein Lupus La
IPR014886 RNA-binding motif
PFAM PF00076
PF05383
PF08777
PRINTS PR00302
PIRSF
SMART SM00360
SM00715
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05455
PhosphoSite PhosphoSite-P05455
TrEMBL Q9UMH7
UniProt Splice Variant
Entrez Gene 6741
UniGene Hs.722305
RefSeq NP_001281074
HUGO HGNC:11316
OMIM 109090
CCDS CCDS2237
HPRD 00168
IMGT
EMBL AB451228 AC009967 BC001289 BC020818 BT009862 CH471058 DQ185046 J04205 M20328 M35261 M35262 M35263 X13697
GenPept AAA36577 AAA36652 AAA36653 AAA36654 AAA51885 AAH01289 AAH20818 AAP88864 AAY14868 ABD14426 BAG70042 CAA31985 EAX11258 EAX11259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca