InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SSB

Summary

InnateDB Gene

IDBG-74582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSB

Gene Name

Sjogren syndrome antigen B (autoantigen La)

Synonyms

La; La/SSB; LARP3

Species

Homo sapiens

Ensembl Gene

ENSG00000138385

Encoded Proteins

IDBP-74584

Sjogren syndrome antigen B (autoantigen La)

IDBP-293711

Sjogren syndrome antigen B (autoantigen La)

IDBP-387376

Sjogren syndrome antigen B (autoantigen La)

IDBP-387377

Sjogren syndrome antigen B (autoantigen La)

IDBP-387378

Sjogren syndrome antigen B (autoantigen La)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. [provided by RefSeq, Nov 2011]
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5\' and 3\' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:169791933-169812064

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000260956	ENSP00000260956
ENST00000409333	ENSP00000386636
ENST00000422006	ENSP00000397029
ENST00000417292	ENSP00000396890
ENST00000413002	ENSP00000395758
ENST00000461708
ENST00000468600
ENST00000474273
ENST00000465871
ENST00000490914
ENST00000470621
ENST00000494051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	67 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396	RNA processing
GO:0006400	tRNA modification
GO:0008334	histone mRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068882

View Gene Order

ENSBTAG00000008716

Not yet available

Pathways

NETPATH

REACTOME

REACT_22339

RNA Polymerase III Abortive And Retractive Initiation pathway

REACT_63

RNA Polymerase III Transcription Termination pathway

REACT_1371

RNA Polymerase III Transcription pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

hsa05322

Systemic lupus erythematosus pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.309316 Hs.457744 Hs.600064 Hs.632535 Hs.701316 Hs.722305

RefSeq

NM_001294145 NM_003142

HUGO

OMIM

CCDS

CCDS2237

HPRD

00168

IMGT

EMBL

GenPept

RNA Seq Atlas