Version 5.4
Homo sapiens Protein: TXN2
Summary
InnateDB Protein IDBP-294030.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN2
Protein Name thioredoxin 2
Synonyms MT-TRX; MTRX; TRX2;
Species Homo sapiens
Ensembl Protein ENSP00000385393
InnateDB Gene IDBG-5938 (TXN2)
Protein Structure
UniProt Annotation
Function Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.
Disease Associations
Tissue Specificity Widely expressed in adult (at protein level) and fetal tissues. {ECO:0000269PubMed:12032145, ECO:0000269PubMed:12080052}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0006662 glycerol ether metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR005746 Thioredoxin
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF PIRSF000077
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99757
PhosphoSite PhosphoSite-Q99757
TrEMBL M0QXH0
UniProt Splice Variant
Entrez Gene 25828
UniGene
RefSeq XP_006724289
HUGO HGNC:17772
OMIM 609063
CCDS CCDS13928
HPRD 07161
IMGT
EMBL AF276920 AF480262 AK301837 AL022313 BC013726 BC050610 CH471095 CR456601 CR541896 CR541917 U78678
GenPept AAB41631 AAF86467 AAH13726 AAH50610 AAN05576 BAG63281 CAG30487 CAG46694 CAG46715 CAQ06700 EAW60103

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca