InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUCB1

Summary

InnateDB Protein

IDBP-294037.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUCB1

Protein Name

nucleobindin 1

Synonyms

CALNUC; NUC;

Species

Homo sapiens

Ensembl Protein

ENSP00000385211

InnateDB Gene

IDBG-61423 (NUCB1)

Protein Structure

UniProt Annotation

Function

Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=A small fraction of the protein may be cytoplasmic. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome