InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRC4

Summary

InnateDB Protein

IDBP-294181.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRC4

Protein Name

NLR family, CARD domain containing 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385428

InnateDB Gene

IDBG-43398 (NLRC4)

Protein Structure

UniProt Annotation

Function

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269PubMed:15107016}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.

Disease Associations

Tissue Specificity

Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002218	activation of innate immune response
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0016045	detection of bacterium
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050702	interleukin-1 beta secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0070269	pyroptosis

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0072557	IPAF inflammasome complex

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NPP4