Homo sapiens Gene: NLRC4 | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-43398.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | NLRC4 | ||||||||||||||||||||||||||||
Gene Name | NLR family, CARD domain containing 4 | ||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000091106 | ||||||||||||||||||||||||||||
Encoded Proteins |
NLR family, CARD domain containing 4
NLR family, CARD domain containing 4
NLR family, CARD domain containing 4
NLR family, CARD domain containing 4
|
||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
NLRC4 is part of the NOD-like receptor family of proteins that consists of more than 20 related family members, that is present in the cytosol and recognizes intracellular ligands.
NLR4C and other NLR proteins function to control IL-1, NF-kappaB, and host response to pathogens, including distinct forms of cell death. NLR4C is important for CASP1 activation and IL-1 processing.
NLRC4 expressed in monocytes associates with NOD2 following exposure to bacterial peptidoglycan, implying a regulatory role for interaction of NACHT-domain containing proteins in the innate immune response.
NLR4C detects the basal body rod component of the T3SS apparatus (rod protein) from S. typhimurium (PrgJ), Burkholderia pseudomallei (BsaK), Escherichia coli (EprJ and EscI), Shigella flexneri (MxiI), and Pseudomonas aeruginosa (PscI) and the specific detection of the virulence machinery permits the discrimination between pathogenic and non-pathogenic bacteria.
The NLRC4 inflammasome is important for control of mucosal Candida infection, impacting on inflammatory cell recruitment to infected tissues, as well as protecting against the systemic dissemination of infection. (Demonstrated in mouse)
Flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells triggers antigen-independent IFN-gamma production by memory T cells. (Demonstrated in mouse)
NLRC4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection. (Demonstrated in mouse)
NLRC4-dependent production of IL1B by intestinal phagocytes is a mechanism that discriminates pathogenic from commensal bacteria in the intestinal host defence. (Demonstrated in mouse)
NLRC4 Serâ??533 phosphorylation is essential for procaspase-1 recruitment to the NLRC4 inflammasome complex after S. typhimurium infection. (Demonstrated in mouse)
|
||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] The Nlrc4 inflammasome is important for control of mucosal Candida infection, impacting on inflammatory cell recruitment to infected tissues, as well as protecting against the systemic dissemination of infection.
[Mus musculus] Flagellin-induced Nlrc4 inflammasome activation in splenic dendritic cells triggers antigen-independent IFN-gamma production by memory T cells.
[Mus musculus] Nlrc4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection.
[Mus musculus] Nlrc4-dependent production of Il1b by intestinal phagocytes is a mechanism that discriminates pathogenic from commensal bacteria in the intestinal host defence.
[Mus musculus] Nlrc4 Serâ??533 phosphorylation is essential for procaspase-1 recruitment to the Nlrc4 inflammasome complex after S. typhimurium infection.
[Mus musculus] Microglial cells employ the NAIP5/NLRC4 inflammasome to monitor and clear central nervous system infections by flagellated bacteria.
[Mus musculus] Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
[Mus musculus] Actin polymerization is required for Nlrc4-dependent regulation of intracellular bacterial burden, inflammasome assembly, pyroptosis, and Il1b production.
|
||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
Summary |
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008] |
||||||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:32224453-32265854 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | p22.3 | ||||||||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||||||
Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
The IPAF inflammasome pathway
Inflammasomes pathway
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
|
||||||||||||||||||||||||||||
KEGG |
NOD-like receptor signaling pathway pathway
|
||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||
PID NCI |
Direct p53 effectors
|
||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Hs.574741 | ||||||||||||||||||||||||||||
RefSeq | NM_001199138 NM_001199139 NM_021209 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS33174 | ||||||||||||||||||||||||||||
HPRD | 06014 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||