Version 5.4
Homo sapiens Protein: GPT2
Summary
InnateDB Protein IDBP-29428.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPT2
Protein Name glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345282
InnateDB Gene IDBG-29426 (GPT2)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. {ECO:0000269PubMed:11863375}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast. {ECO:0000269PubMed:11863375}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042851 L-alanine metabolic process
GO:0042853 L-alanine catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00155
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TD30
PhosphoSite PhosphoSite-Q8TD30
TrEMBL B3KR40
UniProt Splice Variant
Entrez Gene 84706
UniGene Hs.460693
RefSeq NP_597700
HUGO HGNC:18062
OMIM 138210
CCDS CCDS10725
HPRD 06307
IMGT
EMBL AC018845 AK090957 AK094971 AY029173 BC062555 CH471092
GenPept AAH62555 AAK31794 BAC04465 BAG52252 EAW82691 EAW82692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca