Version 5.4
Homo sapiens Protein: LIMS2
Summary
InnateDB Protein IDBP-294345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMS2
Protein Name LIM and senescent cell antigen-like domains 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387002
InnateDB Gene IDBG-69173 (LIMS2)
Protein Structure
UniProt Annotation
Function Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269PubMed:12167643}.
Subcellular Localization Nucleus {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269PubMed:12167643}. Cell membrane {ECO:0000269PubMed:12167643}; Peripheral membrane protein {ECO:0000269PubMed:12167643}; Cytoplasmic side {ECO:0000269PubMed:12167643}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
Biological Process
GO:0034329 cell junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
IPR017351 LIM and senescent cell antigen-like-containing domain protein 1
PFAM PF00412
PRINTS
PIRSF PIRSF038003
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4I7
PhosphoSite PhosphoSite-Q7Z4I7
TrEMBL Q9H058
UniProt Splice Variant
Entrez Gene 55679
UniGene Hs.688940
RefSeq NP_001154876
HUGO HGNC:16084
OMIM 607908
CCDS CCDS54394
HPRD
IMGT
EMBL AC010976 AC074114 AF484961 AF520987 AF527764 AF527765 AF527766 AF527767 AF527770 AK022470 AK297645 AL512716 BC001370 BC008977 BC065816 BX458594 CH471103
GenPept AAH01370 AAH08977 AAH65816 AAM77350 AAM97589 AAQ09011 AAQ09012 AAQ09013 AAQ09014 AAQ09017 BAB14047 BAG60013 CAC21657 EAW95327 EAW95331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca