Homo sapiens Gene: LIMS2
Summary
InnateDB Gene IDBG-69173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMS2
Gene Name LIM and senescent cell antigen-like domains 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072163
Encoded Proteins
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
LIM and senescent cell antigen-like domains 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127638381-127681786
Strand Reverse strand
Band q14.3
Transcripts
ENST00000324938 ENSP00000326888
ENST00000355119 ENSP00000347240
ENST00000410011 ENSP00000387002
ENST00000409808 ENSP00000386637
ENST00000409455 ENSP00000386383
ENST00000409754 ENSP00000386345
ENST00000409286 ENSP00000386252
ENST00000410038 ENSP00000386570
ENST00000409254 ENSP00000386907
ENST00000426981 ENSP00000397253
ENST00000413578 ENSP00000388611
ENST00000469300
ENST00000494613
ENST00000476932
ENST00000484252
ENST00000466410
ENST00000545738 ENSP00000443794
ENST00000582671
ENST00000612860 ENSP00000484949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0034329 cell junction assembly
GO:0043066 negative regulation of apoptotic process
GO:0045216 cell-cell junction organization
GO:0050680 negative regulation of epithelial cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000346 negative regulation of hepatocyte proliferation
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-Cell communication pathway
Cell junction organization pathway
Cell-extracellular matrix interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469881 Hs.688940
RefSeq NM_001136037 NM_001161403 NM_001161404 NM_001256542 NM_017980 XM_005263710 XM_006712627
HUGO
OMIM
CCDS CCDS2147 CCDS54394 CCDS54395 CCDS54396 CCDS58725
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas