InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K2

Summary

InnateDB Protein

IDBP-294373.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K2

Protein Name

mitogen-activated protein kinase kinase kinase 2

Synonyms

MEKK2; MEKK2B;

Species

Homo sapiens

Ensembl Protein

ENSP00000387246

InnateDB Gene

IDBG-69031 (MAP3K2)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269PubMed:10713157, ECO:0000269PubMed:16001074}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15075238}. Nucleus {ECO:0000269PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007257	activation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00666
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt