Homo sapiens Gene: MAP3K2
Summary
InnateDB Gene IDBG-69031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K2
Gene Name mitogen-activated protein kinase kinase kinase 2
Synonyms MEKK2; MEKK2B;
Species Homo sapiens
Ensembl Gene ENSG00000169967
Encoded Proteins
mitogen-activated protein kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127298730-127388465
Strand Reverse strand
Band q14.3
Transcripts
ENST00000344908 ENSP00000343463
ENST00000409947 ENSP00000387246
ENST00000409179 ENSP00000386313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007257 activation of JUN kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
TNFalpha pathway
IL1 pathway
REACTOME
KEGG
MAPK signaling pathway pathway
Gap junction pathway
GnRH signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by the MAPK pathway
ErbB1 downstream signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.145605 Hs.609719 Hs.743676
RefSeq NM_006609
HUGO
OMIM
CCDS CCDS46404
HPRD 10068
IMGT
EMBL
GenPept
RNA Seq Atlas