InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K2

Summary

InnateDB Gene

IDBG-69031.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K2

Gene Name

mitogen-activated protein kinase kinase kinase 2

Synonyms

MEKK2; MEKK2B

Species

Homo sapiens

Ensembl Gene

ENSG00000169967

Encoded Proteins

IDBP-69033

mitogen-activated protein kinase kinase kinase 2

IDBP-294373

mitogen-activated protein kinase kinase kinase 2

IDBP-294370

mitogen-activated protein kinase kinase kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:127298730-127388465

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000344908	ENSP00000343463
ENST00000409947	ENSP00000387246
ENST00000409179	ENSP00000386313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007257	activation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024383

View Gene Order

ENSBTAG00000004216

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_9

TNFalpha pathway

NetPath_13

IL1 pathway

REACTOME

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa04010

MAPK signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

mapktrkpathway

Trk receptor signaling mediated by the MAPK pathway

erbb1_downstream_pathway

ErbB1 downstream signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.145605 Hs.609719 Hs.743676

RefSeq

NM_006609

HUGO

OMIM

CCDS

CCDS46404

HPRD

10068

IMGT

EMBL

GenPept

RNA Seq Atlas