Version 5.4
Homo sapiens Protein: SPAM1
Summary
InnateDB Protein IDBP-294452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAM1
Protein Name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms HEL-S-96n; HYA1; HYAL1; HYAL3; HYAL5; PH-20; PH20; SPAG15;
Species Homo sapiens
Ensembl Protein ENSP00000386028
InnateDB Gene IDBG-39033 (SPAM1)
Protein Structure
UniProt Annotation
Function Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269PubMed:8282124}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Testis. {ECO:0000269PubMed:8234258}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007342 fusion of sperm to egg plasma membrane
GO:0032504 multicellular organism reproduction
GO:0035036 sperm-egg recognition
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017853 Glycoside hydrolase, superfamily
IPR018155 Hyaluronidase
PFAM PF01630
PRINTS PR00846
PIRSF PIRSF038193
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P38567
PhosphoSite PhosphoSite-P38567
TrEMBL C9J2X5
UniProt Splice Variant
Entrez Gene 6677
UniGene Hs.642293
RefSeq
HUGO HGNC:11217
OMIM 600930
CCDS CCDS5790
HPRD 02958
IMGT
EMBL AC004690 BC026163 CH236947 CH471070 L13781 S67798 X84347
GenPept AAC60607 AAH26163 AAQ96882 CAA59086 EAL24329 EAW83606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca