InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAD

Summary

InnateDB Protein

IDBP-294545.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAD

Protein Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384510

InnateDB Gene

IDBG-37744 (CAD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	54 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004070	aspartate carbamoyltransferase activity
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016597	amino acid binding
GO:0016743	carboxyl- or carbamoyltransferase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0046872	metal ion binding

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0008152	metabolic process
GO:0070409	carbamoyl phosphate biosynthetic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002082 Aspartate carbamoyltransferase
IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR006130 Aspartate/ornithine carbamoyltransferase
IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
IPR006274 Carbamoyl-phosphate synthase, small subunit
IPR006275 Carbamoyl-phosphate synthase, large subunit
IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011607 Methylglyoxal synthase-like domain
IPR011761 ATP-grasp fold
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like

PFAM