InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAD

Summary

InnateDB Gene

IDBG-37744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAD

Gene Name

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000084774

Encoded Proteins

IDBP-37748

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

IDBP-294545

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

IDBP-369001

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

IDBP-369003

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

IDBP-369005

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:27217390-27243943

Strand

Forward strand

Band

p23.3

Transcripts

ENST00000264705	ENSP00000264705
ENST00000403525	ENSP00000384510
ENST00000458503	ENSP00000414742
ENST00000456311	ENSP00000388740
ENST00000428460	ENSP00000405416
ENST00000491891
ENST00000464159
ENST00000475695
ENST00000479002
ENST00000487239
ENST00000491461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	54 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004070	aspartate carbamoyltransferase activity
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151	dihydroorotase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016597	amino acid binding
GO:0016743	carboxyl- or carbamoyltransferase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070335	aspartate binding

Biological Process

GO:0001889	liver development
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006541	glutamine metabolic process
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008152	metabolic process
GO:0014075	response to amine
GO:0017144	drug metabolic process
GO:0018107	peptidyl-threonine phosphorylation
GO:0031000	response to caffeine
GO:0031100	organ regeneration
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0044205	'de novo' UMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0046777	protein autophosphorylation
GO:0051414	response to cortisol
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0070409	carbamoyl phosphate biosynthetic process
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome