Version 5.4
Homo sapiens Protein: PSD
Summary
InnateDB Protein IDBP-294612.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSD
Protein Name pleckstrin and Sec7 domain containing
Synonyms EFA6; EFA6A; PSD1; TYL;
Species Homo sapiens
Ensembl Protein ENSP00000384830
InnateDB Gene IDBG-87921 (PSD)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cell projection, ruffle {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 is expressed in the brain. {ECO:0000269PubMed:9417912}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001605 Pleckstrin homology domain, spectrin-type
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS PR00683
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5PKW4
PhosphoSite PhosphoSite-A5PKW4
TrEMBL
UniProt Splice Variant
Entrez Gene 5662
UniGene Hs.743732
RefSeq NP_001257894
HUGO HGNC:9507
OMIM 602327
CCDS CCDS31272
HPRD 09085
IMGT
EMBL AB095931 AL121928 BC142643 BC142689 CH471066 X99688
GenPept AAI42644 AAI42690 BAC23107 CAA68002 CAI12516 EAW49693 EAW49694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca