Homo sapiens Gene: PSD
Summary
InnateDB Gene IDBG-87921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSD
Gene Name pleckstrin and Sec7 domain containing
Synonyms EFA6; EFA6A; PSD1; TYL;
Species Homo sapiens
Ensembl Gene ENSG00000059915
Encoded Proteins
pleckstrin and Sec7 domain containing
pleckstrin and Sec7 domain containing
pleckstrin and Sec7 domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102402617-102421539
Strand Reverse strand
Band q24.32
Transcripts
ENST00000020673 ENSP00000020673
ENST00000406432 ENSP00000384830
ENST00000479172
ENST00000473507
ENST00000461698
ENST00000488194
ENST00000472685
ENST00000492902
ENST00000611678 ENSP00000481250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.154658 Hs.743732
RefSeq NM_001270965 NM_001270966 NM_002779
HUGO
OMIM
CCDS CCDS31272 CCDS73187
HPRD 09085
IMGT
EMBL
GenPept
RNA Seq Atlas