InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A3

Summary

InnateDB Protein

IDBP-294631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A3

Protein Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3

Synonyms

PHC; PTP;

Species

Homo sapiens

Ensembl Protein

ENSP00000383898

InnateDB Gene

IDBG-52270 (SLC25A3)

Protein Structure

UniProt Annotation

Function

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Mitochondrial phosphate carrier deficiency (MPCD) [MIM:610773]: Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. {ECO:0000269PubMed:17273968}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	85 [view]
Protein-Protein	85 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity
GO:0015320	phosphate ion carrier activity
GO:0032403	protein complex binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006810	transport
GO:0035435	phosphate ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome