Version 5.4
Homo sapiens Gene: SLC25A3
Summary
InnateDB Gene IDBG-52270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A3
Gene Name solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Synonyms PHC; PTP
Species Homo sapiens
Ensembl Gene ENSG00000075415
Encoded Proteins
IDBP-52272
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-52274
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-294631
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-589415
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-598601
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-600797
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-603597
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-600438
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-590223
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-598346
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-590189
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
IDBP-596973
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:98593591-98606379
Strand Forward strand
Band q23.1
Transcripts
ENST00000188376 ENSP00000188376
ENST00000228318 ENSP00000228318
ENST00000401722 ENSP00000383898
ENST00000551917 ENSP00000447310
ENST00000546766
ENST00000548046 ENSP00000447339
ENST00000552981 ENSP00000448708
ENST00000551265 ENSP00000448969
ENST00000550695 ENSP00000449479
ENST00000547534 ENSP00000449793
ENST00000549338 ENSP00000447740
ENST00000551123 ENSP00000449009
ENST00000548847 ENSP00000449166
ENST00000547908
ENST00000547444
ENST00000548480
ENST00000547869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
GO:0015320 phosphate ion carrier activity
GO:0032403 protein complex binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006810 transport
GO:0035435 phosphate ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061904
View Gene Order
ENSBTAG00000012890
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL F8VZL5 Q6MZF9
UniProt Splice Variant
Entrez Gene 5250
UniGene Hs.290404
RefSeq NM_002635 NM_005888 NM_213611
HUGO HGNC:10989
OMIM 600370
CCDS CCDS9065 CCDS9066
HPRD 02654
IMGT
EMBL AC013283 BX647062
GenPept CAE46080
RNA Seq Atlas 5250

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca