InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTRC

Summary

InnateDB Protein

IDBP-294721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTRC

Protein Name

beta-transducin repeat containing

Synonyms

BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385339

InnateDB Gene

IDBG-87102 (BTRC)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. {ECO:0000269PubMed:10066435, ECO:0000269PubMed:10497169, ECO:0000269PubMed:10644755, ECO:0000269PubMed:10835356, ECO:0000269PubMed:11238952, ECO:0000269PubMed:11359933, ECO:0000269PubMed:11994270, ECO:0000269PubMed:12791267, ECO:0000269PubMed:12902344, ECO:0000269PubMed:14603323, ECO:0000269PubMed:14681206, ECO:0000269PubMed:14988407, ECO:0000269PubMed:15448698, ECO:0000269PubMed:15917222, ECO:0000269PubMed:16371461, ECO:0000269PubMed:9859996}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in epididymis (at protein level). {ECO:0000269PubMed:20736409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 252 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	252 [view]
Protein-Protein	249 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007165	signal transduction
GO:0016032	viral process
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045862	positive regulation of proteolysis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048511	rhythmic process
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR001810 F-box domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR021977 D domain of beta-TrCP

PFAM

PF00400
PF00646
PF12937
PF13013
PF12125

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00256
SM01028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt