Version 5.4
Homo sapiens Gene: BTRC
Summary
InnateDB Gene IDBG-87102.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTRC
Gene Name beta-transducin repeat containing E3 ubiquitin protein ligase
Synonyms BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Species Homo sapiens
Ensembl Gene ENSG00000166167
Encoded Proteins
IDBP-87104
beta-transducin repeat containing
IDBP-87106
beta-transducin repeat containing
IDBP-243610
beta-transducin repeat containing
IDBP-294721
beta-transducin repeat containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:101354033-101557321
Strand Forward strand
Band q24.32
Transcripts
ENST00000370187 ENSP00000359206
ENST00000370183 ENSP00000359202
ENST00000393441 ENSP00000377088
ENST00000408038 ENSP00000385339
ENST00000475200
ENST00000465182
ENST00000493877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 252 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 252 [view]
Protein-Protein 249 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016874 ligase activity
GO:0045309 protein phosphorylated amino acid binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648 protein destabilization
GO:0033598 mammary gland epithelial cell proliferation
GO:0042752 regulation of circadian rhythm
GO:0042753 positive regulation of circadian rhythm
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045862 positive regulation of proteolysis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048511 rhythmic process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051726 regulation of cell cycle
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0061136 regulation of proteasomal protein catabolic process
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025217
View Gene Order
ENSBTAG00000007476
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_24941
Circadian Clock pathway
REACT_9031
Vpu mediated degradation of CD4 pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_11045
Signaling by Wnt pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_22232
Signaling by Interleukins pathway
REACT_2203
G2/M Transition pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04710
Circadian rhythm pathway
hsa04114
Oocyte meiosis pathway
hsa05131
Shigellosis pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
ps1pathway
Presenilin action in Notch and Wnt signaling
hdac_classi_pathway
Signaling events mediated by HDAC Class I
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
betacatenin_deg_pathway
Degradation of beta catenin
tap63pathway
Validated transcriptional targets of TAp63 isoforms
nfkappabalternativepathway
Alternative NF-kappaB pathway
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643802
RefSeq NM_001256856 NM_003939 NM_033637 XM_005270264 XM_006718054
HUGO
OMIM
CCDS CCDS73183 CCDS7511 CCDS7512
HPRD 04596
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca