InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IMMP2L

Summary

InnateDB Protein

IDBP-294757.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMMP2L

Protein Name

IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384966

InnateDB Gene

IDBG-36525 (IMMP2L)

Protein Structure

UniProt Annotation

Function

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269PubMed:15814844}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305PubMed:15814844}; Single-pass membrane protein {ECO:0000305PubMed:15814844}.

Disease Associations

Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. {ECO:0000269PubMed:11254443}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues tested except adult liver and lung. {ECO:0000269PubMed:11254443}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006508	proteolysis
GO:0006627	protein processing involved in protein targeting to mitochondrion
GO:0007283	spermatogenesis
GO:0030728	ovulation