InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPST2

Summary

InnateDB Protein

IDBP-294858.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPST2

Protein Name

tyrosylprotein sulfotransferase 2

Synonyms

TANGO13B;

Species

Homo sapiens

Ensembl Protein

ENSP00000385192

InnateDB Gene

IDBG-3215 (TPST2)

Protein Structure

UniProt Annotation

Function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9736702}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0008476	protein-tyrosine sulfotransferase activity

Biological Process

GO:0006478

peptidyl-tyrosine sulfation

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60704

PhosphoSite

PhosphoSite-O60704

TrEMBL

B7Z976

UniProt Splice Variant

Entrez Gene

8459

UniGene

RefSeq

HUGO

HGNC:12021

OMIM

603126

CCDS

CCDS13839

HPRD

07217

IMGT

EMBL

AF049891 AF061254 AJ006198 AK074538 AK075139 AK304545 AL136623 BC001057 BC017509 CH471095 CR456597 CR533528 Z95115

GenPept

AAC34296 AAC36061 AAH01057 AAH17509 BAG51969 BAG52071 BAH14212 CAA06906 CAB62950 CAB66558 CAG30483 CAG38559 EAW59726 EAW59728