InnateDB Protein
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IDBP-295027.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HDAC9
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Protein Name
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histone deacetylase 9
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Synonyms
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HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384382
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InnateDB Gene
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IDBG-9049 (HDAC9)
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Protein Structure
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Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein.
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Tissue Specificity |
Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level). {ECO:0000269PubMed:10655483, ECO:0000269PubMed:11535832, ECO:0000269PubMed:12590135, ECO:0000269PubMed:12706107}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
117
[view]
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Protein-Protein |
78
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
38
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003714
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transcription corepressor activity
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GO:0004407
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histone deacetylase activity
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GO:0005080
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protein kinase C binding
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GO:0005515
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protein binding
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GO:0008134
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transcription factor binding
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GO:0032041
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NAD-dependent histone deacetylase activity (H3-K14 specific)
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GO:0033558
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protein deacetylase activity
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GO:0042826
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histone deacetylase binding
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GO:0046872
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metal ion binding
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GO:0046969
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NAD-dependent histone deacetylase activity (H3-K9 specific)
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GO:0046970
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NAD-dependent histone deacetylase activity (H4-K16 specific)
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GO:0070491
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repressing transcription factor binding
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GO:0097372
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NAD-dependent histone deacetylase activity (H3-K18 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR024643
Histone deacetylase, glutamine rich N-terminal domain
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PFAM |
PF12203
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKV0
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PhosphoSite |
PhosphoSite-Q9UKV0
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TrEMBL |
Q75N16
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UniProt Splice Variant |
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Entrez Gene |
9734
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UniGene |
Hs.734495
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RefSeq |
NP_055522
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HUGO |
HGNC:14065
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OMIM |
606543
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CCDS |
CCDS47557
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HPRD |
05944
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IMGT |
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EMBL |
AB018287
AC002088
AC002124
AC002410
AC002433
AC004744
AC004994
AC005249
AC010082
AC074193
AC091697
AF124924
AJ459808
AK297404
AK304298
AK304343
AK304410
AY032737
AY032738
AY197371
BC111735
BC150328
BC152405
CH471073
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GenPept |
AAF04254
AAI11736
AAI50329
AAI52406
AAK66821
AAK66822
AAO27363
AAS07409
AAS07422
AAS07423
AAS07424
BAA34464
BAH12570
BAH14153
BAH14164
BAH14176
CAD30851
EAW93702
EAW93703
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