Version 5.4
Homo sapiens Gene: HDAC9
Summary
InnateDB Gene IDBG-9049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC9
Gene Name histone deacetylase 9
Synonyms HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR
Species Homo sapiens
Ensembl Gene ENSG00000048052
Encoded Proteins
IDBP-295035
histone deacetylase 9
IDBP-295030
histone deacetylase 9
IDBP-295027
histone deacetylase 9
IDBP-295034
histone deacetylase 9
IDBP-366654
histone deacetylase 9
IDBP-366660
histone deacetylase 9
IDBP-366665
histone deacetylase 9
IDBP-366676
histone deacetylase 9
IDBP-366808
histone deacetylase 9
IDBP-366812
histone deacetylase 9
IDBP-366819
histone deacetylase 9
IDBP-366820
histone deacetylase 9
IDBP-366823
histone deacetylase 9
IDBP-366831
histone deacetylase 9
IDBP-366844
histone deacetylase 9
IDBP-480341
histone deacetylase 9
IDBP-810013
histone deacetylase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:18086949-19002416
Strand Forward strand
Band p21.1
Transcripts
ENST00000406451 ENSP00000384657
ENST00000401921 ENSP00000383912
ENST00000405010 ENSP00000384382
ENST00000406072 ENSP00000384017
ENST00000433709 ENSP00000409003
ENST00000413509 ENSP00000412497
ENST00000413380 ENSP00000392564
ENST00000430454 ENSP00000411422
ENST00000446646 ENSP00000415095
ENST00000441542 ENSP00000408617
ENST00000432645 ENSP00000410337
ENST00000428307 ENSP00000395655
ENST00000441986 ENSP00000404763
ENST00000456174 ENSP00000388568
ENST00000417496 ENSP00000401669
ENST00000455069
ENST00000425071
ENST00000411993
ENST00000461159
ENST00000474742
ENST00000476135
ENST00000461409
ENST00000523867
ENST00000471887
ENST00000524023 ENSP00000430036
ENST00000490851
ENST00000483142
ENST00000496026
ENST00000622668 ENSP00000478829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
Experimentally validated
Total 117 [view]
Protein-Protein 78 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 38 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0030183 B cell differentiation
GO:0032869 cellular response to insulin stimulus
GO:0034983 peptidyl-lysine deacetylation
GO:0042113 B cell activation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048742 regulation of skeletal muscle fiber development
GO:0051153 regulation of striated muscle cell differentiation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0035097 histone methyltransferase complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.196054 Hs.640515 Hs.734148 Hs.734495
RefSeq NM_001204144 NM_001204145 NM_001204146 NM_001204147 NM_001204148 NM_014707 NM_058176 NM_178423 NM_178425 XM_006715802 XM_006715803
HUGO
OMIM
CCDS CCDS47553 CCDS47554 CCDS47555 CCDS47557 CCDS56465 CCDS56466 CCDS56467 CCDS56468 CCDS75565
HPRD 05944
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca