InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPT2

Summary

InnateDB Protein

IDBP-295039.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT2

Protein Name

septin 2

Synonyms

DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3;

Species

Homo sapiens

Ensembl Protein

ENSP00000385109

InnateDB Gene

IDBG-85139 (SEPT2)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269PubMed:15774761, ECO:0000269PubMed:17803907, ECO:0000269PubMed:18209106, ECO:0000269PubMed:19145258}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:15774761}. Cleavage furrow {ECO:0000269PubMed:15774761}. Midbody {ECO:0000269PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes.

Disease Associations

Tissue Specificity

Widely expressed. Up-regulated in liver cancer. {ECO:0000269PubMed:15915442, ECO:0000269PubMed:19165576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007224	smoothened signaling pathway
GO:0042384	cilium assembly

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome