Version 5.4
Homo sapiens Protein: NEU4
Summary
InnateDB Protein IDBP-295110.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEU4
Protein Name sialidase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385149
InnateDB Gene IDBG-85340 (NEU4)
Protein Structure
UniProt Annotation
Function May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. {ECO:0000269PubMed:14962670, ECO:0000269PubMed:15213228}.
Subcellular Localization Isoform 1: Membrane; Peripheral membrane protein.Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N- glycosylation site is predicted from the sequence.
Disease Associations
Tissue Specificity Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta. {ECO:0000269PubMed:14962670}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004308 exo-alpha-sialidase activity
GO:0005515 protein binding
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0006516 glycoprotein catabolic process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0008152 metabolic process
GO:0009313 oligosaccharide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005764 lysosome
GO:0019866 organelle inner membrane
GO:0043202 lysosomal lumen
Protein Structure and Domains
PDB ID
InterPro IPR011040 Sialidases
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWR8
PhosphoSite PhosphoSite-Q8WWR8
TrEMBL C9JRN9
UniProt Splice Variant
Entrez Gene 129807
UniGene Hs.551747
RefSeq NP_542779
HUGO HGNC:21328
OMIM 608527
CCDS CCDS2553
HPRD 12249
IMGT
EMBL AC114730 AJ277883 AK091038 AK289421 AK300969 AY203952 BC012899 CH471063
GenPept AAH12899 AAP34475 AAX82022 BAF82110 BAG52266 BAH13385 CAC81904 EAW71295 EAW71296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca