InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1R1

Summary

InnateDB Protein

IDBP-295120.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1R1

Protein Name

interleukin 1 receptor, type I

Synonyms

CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80;

Species

Homo sapiens

Ensembl Protein

ENSP00000386380

InnateDB Gene

IDBG-64088 (IL1R1)

Protein Structure

UniProt Annotation

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269PubMed:10671496}.

Subcellular Localization

Membrane {ECO:0000269PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269PubMed:8142597}. Cell membrane {ECO:0000305PubMed:8142597}. Secreted {ECO:0000269PubMed:8142597}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004908	interleukin-1 receptor activity
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004076 Interleukin-1 receptor type 1
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01582
PF13676
PF07679

PRINTS

PR01536
PR01538

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt