InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1R1

Summary

InnateDB Protein

IDBP-295121.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1R1

Protein Name

interleukin 1 receptor, type I

Synonyms

CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80;

Species

Homo sapiens

Ensembl Protein

ENSP00000386776

InnateDB Gene

IDBG-64088 (IL1R1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004076 Interleukin-1 receptor type 1
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01582
PF13676
PF07679

PRINTS

PR01536
PR01538

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt