InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCG2

Summary

InnateDB Protein

IDBP-29519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCG2

Protein Name

ATP-binding cassette, sub-family G (WHITE), member 2

Synonyms

ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000237612

InnateDB Gene

IDBG-29517 (ABCG2)

Protein Structure

UniProt Annotation

Function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO:0000269PubMed:12958161, ECO:0000269PubMed:20705604, ECO:0000269PubMed:22132962, ECO:0000269PubMed:23189181}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in placenta. Low expression in small intestine, liver and colon. {ECO:0000269PubMed:9850061, ECO:0000269PubMed:9861027}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0015232	heme transporter activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006879	cellular iron ion homeostasis
GO:0015886	heme transport
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0044281	small molecule metabolic process
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF01061

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UNQ0