Homo sapiens Gene: ABCG2 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-29517.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | ABCG2 | ||||||||||||||||||||
Gene Name | ATP-binding cassette, sub-family G (WHITE), member 2 | ||||||||||||||||||||
Synonyms | ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1 | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000118777 | ||||||||||||||||||||
Encoded Proteins |
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 4:88090264-88231322 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | q22.1 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Iron uptake and transport pathway
Abacavir transmembrane transport pathway
Transmembrane transport of small molecules pathway
Abacavir transport and metabolism pathway
Metabolism pathway
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KEGG |
ABC transporters pathway
Bile secretion pathway
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INOH | |||||||||||||||||||||
PID NCI |
HIF-2-alpha transcription factor network
HIF-1-alpha transcription factor network
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
UniGene | Hs.480218 Hs.641926 | ||||||||||||||||||||
RefSeq | NM_001257386 NM_004827 XM_005263354 XM_005263355 XM_005263356 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS3628 CCDS58910 | ||||||||||||||||||||
HPRD | 04783 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||