Homo sapiens Gene: ABCG2
Summary
InnateDB Gene IDBG-29517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCG2
Gene Name ATP-binding cassette, sub-family G (WHITE), member 2
Synonyms ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1;
Species Homo sapiens
Ensembl Gene ENSG00000118777
Encoded Proteins
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88090264-88231322
Strand Reverse strand
Band q22.1
Transcripts
ENST00000237612 ENSP00000237612
ENST00000515655 ENSP00000426917
ENST00000505480 ENSP00000426916
ENST00000503830 ENSP00000426934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008559 xenobiotic-transporting ATPase activity
GO:0015232 heme transporter activity
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0042803 protein homodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006855 drug transmembrane transport
GO:0006879 cellular iron ion homeostasis
GO:0015886 heme transport
GO:0042493 response to drug
GO:0042908 xenobiotic transport
GO:0044281 small molecule metabolic process
GO:0046415 urate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Abacavir transmembrane transport pathway
Abacavir transport and metabolism pathway
Metabolism pathway
KEGG
ABC transporters pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
HIF-2-alpha transcription factor network
HIF-1-alpha transcription factor network
Cross-References
SwissProt Q9UNQ0
TrEMBL F8S0F2
UniProt Splice Variant
Entrez Gene 9429
UniGene Hs.480218 Hs.641926
RefSeq NM_001257386 NM_004827 XM_005263356 XM_005263355 XM_005263354
HUGO HGNC:74
OMIM 603756
CCDS CCDS58910 CCDS3628
HPRD 04783
IMGT
EMBL AB051855 AB056867 AC084732 AC097484 AF093771 AF093772 AF098951 AF103796 AF463519 AK002040 AK290000 AY017168 AY288307 AY289766 AY333755 AY333756 BC021281 BC092408 DQ996467 HQ386990 HQ386991 HQ386992 HQ386993 HQ386994 HQ386995 HQ386996 HQ386997 HQ386998 HQ386999 HQ387000 HQ387001 HQ387002 HQ387003 HQ387004 HQ387005
GenPept AAC97367 AAD09188 AAG52982 AAH21281 AAH92408 AAO14617 AAP31310 AAP44087 AAQ92941 AAQ92942 AAY40902 ABI97388 ADO95109 ADO95110 ADO95111 ADO95112 ADO95113 ADO95114 ADO95115 ADO95116 ADO95117 ADO95118 ADO95119 ADO95120 ADO95121 ADO95122 ADO95123 ADO95124 BAA92050 BAB39212 BAB46933 BAF82689
RNA Seq Atlas 9429