InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCG2

Summary

InnateDB Gene

IDBG-29517.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCG2

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 2

Synonyms

ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1

Species

Homo sapiens

Ensembl Gene

ENSG00000118777

Encoded Proteins

IDBP-29519

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-482399

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-485231

ATP-binding cassette, sub-family G (WHITE), member 2

IDBP-477426

ATP-binding cassette, sub-family G (WHITE), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:88090264-88231322

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000237612	ENSP00000237612
ENST00000515655	ENSP00000426917
ENST00000505480	ENSP00000426916
ENST00000503830	ENSP00000426934

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0015232	heme transporter activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006879	cellular iron ion homeostasis
GO:0015886	heme transport
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0044281	small molecule metabolic process
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029802

View Gene Order

ENSBTAG00000017704

Not yet available

Pathways

NETPATH

REACTOME

REACT_25060

Iron uptake and transport pathway

REACT_120801

Abacavir transmembrane transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_121189

Abacavir transport and metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa02010

ABC transporters pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

hif2pathway

HIF-2-alpha transcription factor network

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.480218 Hs.641926

RefSeq

NM_001257386 NM_004827 XM_005263354 XM_005263355 XM_005263356

HUGO

OMIM

CCDS

CCDS3628 CCDS58910

HPRD

04783

IMGT

EMBL

GenPept

RNA Seq Atlas