InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH3D19

Summary

InnateDB Protein

IDBP-295235.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3D19

Protein Name

SH3 domain containing 19

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387030

InnateDB Gene

IDBG-41089 (SH3D19)

Protein Structure

UniProt Annotation

Function

May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269PubMed:14551139, ECO:0000269PubMed:15280379, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14551139}. Nucleus {ECO:0000269PubMed:14551139}. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes. {ECO:0000269PubMed:15280379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006892	post-Golgi vesicle-mediated transport
GO:0007010	cytoskeleton organization
GO:0022604	regulation of cell morphogenesis
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0061024	membrane organization