Version 5.4
Homo sapiens Gene: SH3D19
Summary
InnateDB Gene IDBG-41089.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3D19
Gene Name SH3 domain containing 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109686
Encoded Proteins
IDBP-41091
SH3 domain containing 19
IDBP-295236
SH3 domain containing 19
IDBP-295235
SH3 domain containing 19
IDBP-378587
SH3 domain containing 19
IDBP-479848
SH3 domain containing 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:151102751-151325632
Strand Reverse strand
Band q31.3
Transcripts
ENST00000304527 ENSP00000302913
ENST00000409252 ENSP00000386848
ENST00000409598 ENSP00000387030
ENST00000427414 ENSP00000415694
ENST00000478503
ENST00000514152 ENSP00000423449
ENST00000508492
ENST00000462257
ENST00000474743
ENST00000514013
ENST00000604922
ENST00000604030
ENST00000604440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070064 proline-rich region binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028082
View Gene Order
ENSBTAG00000016813
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5HYK7
TrEMBL
UniProt Splice Variant
Entrez Gene 152503
UniGene Hs.567725 Hs.596387 Hs.730818
RefSeq XM_006714098 XM_006714099 XM_006714100 XM_006714101 NM_001009555 NM_001128923 NM_001128924 NM_001243349 XM_005262766 XM_005262767 XM_006714097 XM_006714102
HUGO HGNC:30418
OMIM 608674
CCDS CCDS34077 CCDS47143 CCDS47144
HPRD 16364
IMGT
EMBL AC095055 AK291025 AK294476 AL133047 BC032468 BC045742 BC085613 BC108890 BC108891 BC108892 BC108893 BX647422 CH471056
GenPept AAH32468 AAH45742 AAH85613 AAI08891 AAI08892 AAI08893 AAI08894 BAF83714 BAH11782 CAB61374 CAI46052 EAX04986
RNA Seq Atlas 152503

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca