InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGA1

Summary

InnateDB Protein

IDBP-295277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGA1

Protein Name

high mobility group AT-hook 1

Synonyms

HMG-R; HMGA1A; HMGIY;

Species

Homo sapiens

Ensembl Protein

ENSP00000385693

InnateDB Gene

IDBG-83311 (HMGA1)

Protein Structure

UniProt Annotation

Function

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	76 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046965	retinoid X receptor binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006268	DNA unwinding involved in DNA replication
GO:0006284	base-excision repair
GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0016032	viral process
GO:0031936	negative regulation of chromatin silencing
GO:0035986	senescence-associated heterochromatin focus assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0075713	establishment of integrated proviral latency
GO:0090402	oncogene-induced cell senescence
GO:2000774	positive regulation of cellular senescence